AOP4EUpest

AOP4EUpest extracts and links pesticide–biological event co-occurrences to Adverse Outcome Pathways (AOPs) to support mechanistic assessment of pesticide-induced health effects.

Key Features:

• Annotated Database: An annotated repository of pesticide-associated biological events linked to AOP-Wiki entries.
• Integration with Scientific Literature: Uses the AI-based AOP-helpFinder to identify co-occurrences between specific pesticides and biological events in PubMed abstracts.
• Structured Pathway Mapping: Organizes and links molecular initiating events (MIEs), key events (KEs), and adverse outcomes (AOs) to represent mechanistic pathways.
• Support for Regulatory Assessment: Facilitates identification of biomarkers and prioritization of pesticides for further investigation based on mechanistic links.
• Facilitation of New Studies: Generates mechanistic hypotheses to guide epidemiological and experimental studies on pesticide health impacts.

Scientific Applications:

• Health Risk Assessment: Maps mechanistic pathways to support assessment of long-term risks including neurodevelopmental disorders, carcinogenicity, and endocrine disruption leading to reproductive and metabolic disorders.
• Research and Development: Identifies knowledge gaps and mechanistic questions to inform targeted experimental and epidemiological study design.
• Policy Making: Provides mechanistic evidence to inform regulatory prioritization and policy decisions regarding pesticides.

Methodology:

AOP4EUpest applies the AI-based AOP-helpFinder to mine PubMed abstracts for pesticide–biological event co-occurrences, extracts relevant data, and maps those events to AOP-Wiki entries to link MIEs, KEs, and AOs.