apocand

apocand compiles genomic, proteomic, and structural data for 82 human apoptosis-related proteins to support analysis of apoptotic pathways and genetic alterations in cancer.

Key Features:

• Extensive Protein Data: Contains detailed information on 82 apoptosis-related proteins, including mutation calls, copy number variations, and expression profiles across thousands of tumor samples and cancer cell lines.
• Mutation Analysis: Reports mutation frequencies and highlights frequently mutated apoptosis-related genes such as TP53 and MYD88 across cancer datasets.
• Multifaceted Molecular Annotations: Integrates gene essentiality data, tertiary structure information, sequence alignments and profiles, and post-translational modification annotations.

Scientific Applications:

• Genomic Alteration Profiling: Investigate mutation, copy number variation, and expression patterns of apoptosis proteins across cancers.
• Target Prioritization: Explore potential therapeutic targets by analyzing mutation patterns and gene essentiality data for apoptosis-related genes.
• Comparative Structural and Sequence Analysis: Conduct comparative studies using sequence alignments, profiles, and tertiary structures to assess protein function and interactions.
• Post-translational Modification Studies: Examine how post-translational modifications of apoptosis proteins may influence activity and cancer progression.

Methodology:

Integration and curation of genomic and proteomic data from thousands of tumor samples and cancer cell lines, including mutation, copy number variation, and expression datasets.