Apollo Genome Annotation and Curation Tool

Apollo Genome Annotation and Curation Tool enables interactive exploration, visualization, and expert curation of genomic annotations to refine computational predictions and produce accurate gene models.

Key Features:

• Interactive Genome Annotation Viewer: Allows exploration and visualization of genomic annotations at multiple levels of detail.
• Expert Annotation Curation: Enables editing of existing annotations based on evaluation of supporting data to correct computational predictions.
• Graphical Environment: Provides graphical visualization of genomic elements and their relationships.
• Integration of Computational Predictions and Human Curation: Supports combining automated predictions with manual edits to reconcile discrepancies between algorithms and expert knowledge.
• Support for Custom Annotation Editing Tools: Serves as a starting point for development of customized annotation editing workflows for different organisms.

Scientific Applications:

• Drosophila melanogaster genome annotation (FlyBase): Used by FlyBase biologists to annotate the Drosophila melanogaster genome.
• Genome annotation projects across organisms: Serves as a foundational platform for refining gene models and developing organism-specific annotation editing tools.

Methodology:

Integrates computational predictions with expert human curation by allowing curators to inspect and directly modify annotations.