ELM

ELM annotates eukaryotic linear motifs in proteins, providing information on their function and evolution.

Key Features:

• Motif Search: Users can search for eukaryotic linear motifs and view their annotations.
• Cross-Species Exploration: Users can explore motif presence across different species.
• Functional Annotation: The resource provides information on motif function and evolution.

Scientific Applications:

• Transcription Factor Evolution Studies: ELM annotations support tracing of functionally active linear motifs, such as those in the androgen receptor, across species from cartilaginous fish to Homo sapiens.
• Post-Translational Modification Analysis: ELM data aids identification of motifs dynamically regulated via phosphorylation and other PTMs in protein families such as steroid hormone receptors.
• Protein Domain Analysis: ELM annotations facilitate study of motif conservation and emergence within specific protein domains, including ligand-binding domains.

Methodology:

Not explicitly detailed in sources beyond curation and annotation of eukaryotic linear motifs with functional and evolutionary information.