ASD

ASD catalogs and annotates allosteric proteins and modulators to support analysis of protein allostery and aid allosteric drug discovery.

Key Features:

• Comprehensive Data Collection: Aggregates data on 336 allosteric proteins across 101 species and 8095 modulators categorized as activators, inhibitors, and regulators.
• Detailed Annotations: Provides protein-level annotations of allostery mechanisms, influenced biological processes, and related diseases, and modulator-level data on binding affinity, physicochemical properties, and therapeutic applications.

Scientific Applications:

• Identification of Allosteric Sites: Enables identification of specific allosteric sites within protein families to support experimental validation and targeted therapeutic intervention.
• Drug Design and Discovery: Curates modulators and their properties to inform medicinal chemistry and the structural optimization of allosteric compounds.
• Bridging Biology and Chemistry: Supports mechanistic studies of protein regulation and the rational design of modulators with therapeutic potential.

Methodology:

ASD employs a structured approach to data curation with rigorous scientific validation of entries and continuous updates.