ASFVdb

ASFVdb provides integrated genomic and proteomic data and analyses for African swine fever virus (ASFV), enabling comparative genomics, population genetics, and protein functional and structural characterization.

Key Features:

• Comprehensive Genomic Annotation: Reannotates known ASFV genes across strains and introduces annotations for 5,352 possible open reading frames (ORFs) in 45 ASFV strains.
• Population Genetics Analysis: Conducts population genetics analyses across published ASFV genomes to identify conserved regions and regions with high mutation rates.
• Functional and Structural Predictions: Provides per-gene functional annotations and structural predictions, including predicted subcellular localization and topology.
• Genome Browser with Sliding-Window Analyses: Implements a genome browser using a sliding-window approach to display population genetic metrics and per-window analysis results.

Scientific Applications:

• Comparative Genomics: Facilitates comparison of genomic data across ASFV strains to identify genetic variation and evolutionary trends related to virulence and transmission.
• Proteomic Studies: Supports proteomic analyses by supplying functional and structural annotations to aid identification of candidate therapeutic or vaccine targets.
• Epidemiological Research: Enables tracking of ASFV strain spread and evolutionary dynamics through population genetics analyses.

Methodology:

Reannotation of ASFV genes across 45 strains yielding 5,352 predicted ORFs; population genetics analyses of published ASFV genomes including sliding-window metrics to identify conserved and variable regions; per-gene functional annotation and structural prediction including subcellular localization and topology.