ATIVS

ATIVS analyzes serological and hemagglutinin (HA1) sequence data to support surveillance of human influenza A/H3N2 and assessment of antigenic drift for vaccine strain selection.

Key Features:

• Serological Data Analysis: Processes serological data from all influenza virus types and provides interpretive summaries to characterize immune responses to strains.
• Hemagglutinin (HA1) Sequence Comparison: Compares HA1 sequences of circulating viruses with reference vaccine strains to identify substitutions associated with antigenic drift in influenza A/H3N2.
• Antigenic Mapping: Generates antigenic maps that visualize evolutionary trajectories of influenza viruses and help identify emerging strains with antigenic differences.

Scientific Applications:

• Surveillance: Supports global influenza surveillance efforts, including use within the WHO Global Influenza Surveillance Network, by tracking antigenic evolution over time.
• Vaccine Strain Selection: Informs vaccine strain assessment by providing insights into antigenic drift patterns between circulating viruses and vaccine references.

Methodology:

ATIVS employs genetic and antigenic analyses by integrating serological data and hemagglutinin (HA1) sequence comparisons to construct a comprehensive view of influenza virus evolution and predict antigenic changes.