ATLASx

ATLASx maps biochemical space to identify known and putative enzymatic reactions and metabolic pathways, aiding exploration of metabolic "dark matter".

Key Features:

• Extensive Reaction Mapping: ATLASx employs 490 generalized enzymatic reaction rules to map known and previously unidentified metabolic processes.
• Large-Scale Database Integration: The platform integrates nearly 2 million compounds, built upon an existing repository containing approximately 1.5 million biological compounds.
• Prediction Capabilities: ATLASx predicts over 5 million potential reactions to expand the set of plausible biochemical pathways.
• Global Network Integration: Predicted and known reactions are incorporated into a global network of biochemical knowledge.

Scientific Applications:

• Metabolic engineering: Supports identification of novel biosynthetic routes for engineering biosynthetic cell factories.
• Synthetic biology: Enables exploration of biochemical vicinities for pathway design and molecule derivation.
• Drug discovery: Assists identification of naturally derived pharmaceuticals and potential therapeutic compounds.
• Molecule-context analysis: Aids evaluation of the biochemical context of specific molecule classes.

Methodology:

ATLASx applies 490 generalized enzymatic reaction rules across an integrated database of nearly 2 million compounds (based on ~1.5 million biological compounds) to predict over 5 million potential reactions and incorporate them into a global biochemical network.