ATOLL

ATOLL projects transmembrane helix bundles from 3D membrane protein structures onto the lipid bilayer plane to generate 2D layouts for comparative structural analysis.

Key Features:

• Projection onto lipid bilayer plane: Projects transmembrane helix bundles from 3D structures onto the plane of the lipid bilayer.
• 3D-to-2D flattening for comparison: Flattens 3D structures into 2D layouts to enable comparison of different structural conformations or across membrane proteins.
• Visualization and comparative analysis: Produces comprehensible 2D diagrams of transmembrane helix bundles to support structural analysis.
• Implementation: Implemented in Python3.

Scientific Applications:

• Structural biology visualization: Visual analysis of transmembrane helix bundle arrangements in membrane proteins.
• Elucidating structural basis of function: Comparison of helix-bundle arrangements to support interpretation of membrane protein function.
• Drug design support: Enables comparison of helix-bundle conformations relevant to structure-based drug design.
• Membrane protein dynamics: Supports study of conformational changes and dynamics by comparing different structural states.

Methodology:

Projects transmembrane helix bundles onto the lipid bilayer plane and flattens 3D structures into 2D layouts; implemented in Python3.