AutoGRAPH

AutoGRAPH performs automated multi-species comparative genomics analyses to identify conserved segments (CS), breakpoint regions, and chromosomal rearrangements for studying genomic conservation and evolutionary relationships.

Key Features:

• Conserved Segments and Breakpoints: Identifies conserved segments (CS) and breakpoint regions across genomes.
• Marker/Gene Order Conservation: Assesses conservation of marker or gene order between organisms.
• Synteny Map Construction: Constructs detailed synteny maps for two to three species.
• Chromosomal Rearrangement Detection: Detects chromosomal rearrangements including inversions, translocations, and other structural variations.
• Integration of Genomic Resources: Integrates and compares meiotic maps, radiation hybrid maps, and genome sequences within a species.
• Macrosynteny and Microsynteny Analysis: Analyzes macrosynteny and microsynteny relationships and identifies evolutionary breakpoints.
• Dataset Support: Operates on both personal datasets and pre-inserted public datasets.

Scientific Applications:

• Evolutionary Analysis: Characterizes evolutionary relationships and chromosomal dynamics via conserved segments and breakpoint identification.
• Comparative Genomics: Compares genomic conservation and rearrangements across multiple species.
• Structural Variation Mapping: Maps inversions, translocations, and other structural variations to study genome organization.
• Integrative Genomic Analysis: Combines meiotic maps, radiation hybrid maps, and genome sequences to resolve within-species genome organization.

Methodology:

Automated identification of synteny relationships (macrosynteny and microsynteny), detection of conserved segments (CS) and breakpoint regions, and generation of synteny maps for two to three species using personal and pre-inserted public datasets with integration of meiotic maps, radiation hybrid maps, and genome sequences.