AutonoMS

AutonoMS automates ion mobility mass spectrometry (IM-MS) experiments to enable high-throughput acquisition, processing, and metabolomic fingerprinting workflows.

Key Features:

• Automation and Integration: Automates running, processing, and analysis of IM-MS experiments and integrates with laboratory hardware.
• Software Agent-Controlled Operations: Employs software agents to control measurement and analysis runs based on experimental specification files.
• Specification File Support: Accepts experimental specification files that can be generated by human users or upstream software processes to define runs.
• High-Throughput Capability: Supports flow-injection ion mobility configurations with sample analysis times as short as 5 seconds per sample.
• Versatility and Adaptability: Can be adapted to other analytical instruments and data processing workflows beyond IM-MS.
• Consistency and Reliability: Demonstrates reproducible operation across different experimental conditions.

Scientific Applications:

• Targeted metabolomics: Enables automated targeted analyses in metabolomics experiments using IM-MS.
• Untargeted metabolomics: Supports untargeted metabolomic fingerprinting workflows with high-throughput acquisition.
• Standard and sample processing: Processes robotically prepared chemical standards and cultured yeast samples for analytical studies.
• Closed-loop laboratory workflows: Facilitates development of automated and closed-loop experimental workflows in mass spectrometry research.

Methodology:

Automated software agents manage sample injection, data acquisition, processing, and analysis, with runs specified by experimental specification files produced by users or upstream software.