B3Pdb

B3Pdb provides a curated database of 1,225 experimentally characterized blood-brain barrier-penetrating peptides annotated with mode of delivery, animal models, in vitro and in vivo assays, chemical modifications, and peptide length to support rational design of therapeutics for central nervous system (CNS) disorders.

Key Features:

• Extensive Data Collection: Compiles experimental data on 1,225 BBB-penetrating peptides with annotations for mode of delivery, animal models, and in vitro and in vivo experiments.
• Chemical Modifications and Structural Information: Records chemical modifications and structural characteristics such as peptide length for each entry.
• Support for Rational Design: Provides curated annotations intended to inform rational design and optimization of peptide-based CNS therapeutics.

Scientific Applications:

• Drug Discovery: Enables identification and comparison of peptide candidates capable of crossing the BBB.
• Therapeutic Development: Informs design and optimization of peptide-based therapeutics for CNS disorders.
• Research Advancement: Facilitates analysis and hypothesis generation about determinants of BBB penetration.

Methodology:

Compilation and curation of published experimental data with manual annotation of mode of delivery, animal models, in vitro and in vivo assays, chemical modifications, and peptide length.