BacWGSTdb

BacWGSTdb performs bacterial genome sequence typing and source tracking to characterize pathogenic and multidrug-resistant bacteria from whole-genome sequence data.

Key Features:

• Core Genome MLST (cgMLST) Integration: Implements core genome multi-locus sequence typing (cgMLST) for scalable sequence typing across lineages.
• Multiple Genome Analysis Module: Supports batch processing and comparative analysis of dozens of genome sequences.
• Source Tracking Module: Compares uploaded plasmid sequences against public databases to aid identification of infection sources.
• Integrated Genome and Metadata Repository: Contains an integrated collection of bacterial genome sequencing data linked with corresponding metadata.
• Expanded Species Coverage: Includes 20 bacterial species with a focus on pathogens of medical importance.

Scientific Applications:

• Hospital-acquired infection investigation: Enables genomic classification and comparison of isolates implicated in hospital-acquired infections.
• Foodborne illness source tracing: Facilitates tracing of bacterial strains involved in foodborne illness outbreaks.
• Surveillance of pathogenic and multidrug-resistant bacteria: Supports epidemiological surveillance and characterization of pathogenic and multidrug-resistant bacteria.

Methodology:

Uses core genome multi-locus sequence typing (cgMLST), batch comparative analysis of dozens of genome sequences, plasmid-sequence comparison against public databases, and an integrated repository of bacterial genome sequences with associated metadata.