BALDR
BALDR performs automated comparison and prioritization of biomarker candidates for type 2 diabetes mellitus by integrating protein, gene, disease-related, text-mined, and experimental data from human and mouse IMI2 RHAPSODY studies.
Key Features:
- Comprehensive data integration: Aggregates protein, gene, and disease-related information from major public repositories alongside text-mining outputs and experimental datasets from human and mouse IMI2 RHAPSODY studies.
- Automated pipeline: Automates comparison and prioritization of biomarker candidates across integrated datasets.
- Comparative outputs: Generates comparative analyses presented as figures and tables enabling direct comparison of up to 20 biomarker candidates.
- Evidence integration: Combines computational text-mining evidence with experimental results to support data-driven prioritization.
Scientific Applications:
- Biomarker discovery and prioritization: Assists identification and ranking of promising biomarkers for type 2 diabetes mellitus using integrated multi-source evidence.
- Candidate selection for validation: Supports selection and resource prioritization for downstream experimental verification of biomarker candidates.
Methodology:
Systematic data integration and analysis using computational text-mining techniques and experimental datasets, processed by an automated pipeline to produce comparative analyses.
Topics
Details
- Cost:
- Free of charge
- Tool Type:
- web application
- Operating Systems:
- Mac, Linux, Windows
- Programming Languages:
- R
- Added:
- 2/26/2024
- Last Updated:
- 11/24/2024
Operations
Data Inputs & Outputs
Gene-set enrichment analysis
Publications
Lundgaard AT, Burdet F, Siggaard T, Westergaard D, Vagiaki D, Cantwell L, Röder T, Vistisen D, Sparsø T, Giordano GN, Ibberson M, Banasik K, Brunak S. BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus. PLOS Computational Biology. 2023;19(8):e1011403. doi:10.1371/journal.pcbi.1011403. PMID:37590326. PMCID:PMC10464978.