BCO App

BCO App generates, validates, and enables exploration of BioCompute Objects (BCOs) to standardize and communicate next-generation sequencing and high-throughput sequencing (HTS) computational workflows in accordance with IEEE 2791-2020.

Key Features:

• BCO creation: Generates BioCompute Objects from workflow metadata and computational environments.
• Input formats: Accepts plaintext workflow metadata and workflows written in the Common Workflow Language (CWL).
• Validation: Performs validation of BCOs consistent with the IEEE 2791-2020 standard.
• CGC integration: Integrates with the Cancer Genomics Cloud (CGC) to access and ingest task execution results.
• Auto-population: Auto-populates workflow information fields from existing workflow and task execution data.
• Export formats: Exports BioCompute Objects as JSON and PDF files.
• Publishing: Publishes BioCompute Objects to the Cancer Genomics Cloud (CGC) and GitHub repositories.
• Exploration: Enables exploration of BCO contents for review and inspection.

Scientific Applications:

• Regulatory submissions: Supports preparation of BCOs for inclusion in the Food and Drug Administration (FDA) Data Standards Catalog for HTS submissions.
• Next-generation sequencing (NGS) analysis: Standardizes and communicates computational workflows for NGS and high-throughput sequencing analyses.
• Precision medicine and genomics: Facilitates reproducible workflow description and provenance capture for precision medicine and genomic studies.
• Data sharing and reproducibility: Enables sharing of standardized workflow descriptions across academia, government agencies, and industry.

Methodology:

Generate BCOs from plaintext or Common Workflow Language inputs; access and ingest task execution results from the Cancer Genomics Cloud (CGC); auto-populate workflow information fields from workflow and task execution data; validate BCOs according to IEEE 2791-2020; export as JSON or PDF; publish to CGC and GitHub.