BDdb

BDdb aggregates curated multi-omics and circulating free DNA (cfDNA) datasets to support analysis of molecular mechanisms and biomarkers underlying birth defects.

Key Features:

• Multi-Omics Integration: Integrates multi-omics datasets, including next-generation sequencing (NGS) and other high-throughput sequencing (HTS) data, together with circulating free DNA (cfDNA).
• Extensive Biomarker Repository: Contains over 2000 biomarkers associated with 22 types of birth defects across five species.
• Comprehensive Data Sets: Includes data from 138 Gene Expression Omnibus Series (GSE), 5271 GEO Sample (GSM) entries, and 328 additional datasets.
• Re-analysis and Normalization: Raw datasets were re-analyzed and normalized to provide consistent data for downstream analyses.
• Customizable Data Analysis: Enables customized analyses leveraging the integrated HTS-derived datasets and biomarkers.

Scientific Applications:

• Molecular Regulatory Insights: Supports identification of molecular regulatory mechanisms involved in birth defects through integrated multi-omics and biomarker data.
• Prenatal Screening and Diagnosis: Supports development and evaluation of biomarkers for prenatal screening and diagnostic studies using cfDNA and other omics data.
• Cross-Species Comparative Studies: Enables comparative analyses across five species to identify conserved genetic pathways and potential translational targets.

Methodology:

BDdb integrated multi-omics datasets, circulating free DNA (cfDNA) data, and disease biomarkers from multiple laboratories, and the raw data were re-analyzed and normalized.