Better Bunny

Better Bunny augments functional annotation of rabbit (Oryctolagus cuniculus) genes by leveraging orthologous relationships and data from public bioinformatics repositories to expand gene function characterization for rabbit gene expression studies.

Key Features:

• Augmented Annotation: Expands functional annotation of rabbit (Oryctolagus cuniculus) genes by transferring information from orthologs in other species.
• Orthologue Analysis: Identifies and analyzes homologous genes across species to infer gene function from well-annotated genomes.
• Integration with Public Repositories: Aggregates data extracted from multiple public bioinformatics repositories to enrich rabbit gene annotations.
• Microarray Benchmarking: Benchmarked on the complete set of target genes from a commercial rabbit gene expression microarray, providing functional information for 88% of genes compared with fewer than 10% by previous tools.

Scientific Applications:

• Genetics: Supports functional interpretation of rabbit gene sets in genetic studies.
• Developmental Biology: Enables pathway and gene function analysis in developmental biology experiments using rabbit models.
• Disease Modeling: Facilitates characterization of genes and pathways relevant to human disease modeling in rabbit (Oryctolagus cuniculus) studies.
• Gene Expression Analysis: Provides functional annotation for large gene sets derived from rabbit gene expression assays, including commercial microarrays.

Methodology:

Extracts data from multiple public bioinformatics repositories and uses orthologous relationships to infer and augment functional annotations for rabbit genes.