BGMDB

BGMDB compiles experimentally validated associations between gut microbiota and brain diseases, integrating neurotransmitter interactions and genetic data to support mechanistic insights into gut-brain interactions.

Key Features:

• Curated Gut-Brain Associations: Documents 1419 associations involving 609 gut microbiota taxa and 43 brain disorders.
• Tripartite Neurotransmitter Interactions: Catalogs 184 interactions linking brain diseases, neurotransmitters, and microbiota across six neurotransmitter systems.
• Genetic Data Integration: Integrates genetic data from the gutMGene database to explore microbiota-mediated genetic associations with brain disease pathology and neuroanatomical alterations.

Scientific Applications:

• Neurological Disease Research: Supports investigation of gut microbiota dysbiosis in the etiology and progression of brain disorders.
• Therapeutic Strategy Development: Facilitates identification of microbiota-targeted therapeutic interventions for neurological disorders.
• Gut-Brain Mechanism Elucidation: Advances understanding of neurotransmitter-mediated gut-brain communication and genetic factors in disease pathology.

Methodology:

Rigorous curation of experimentally validated relationships from published literature.