BIND: The Biomolecular Interaction Network Db

BIND: The Biomolecular Interaction Network Db catalogs detailed biomolecular interactions, molecular complexes, and pathways to support proteomics and systems biology analyses.

Key Features:

• Data archiving: Stores extensive records of biomolecular interactions derived from experiments including yeast two-hybrid assays, mass spectrometry, genetic interaction studies, and phage display.
• Data specification (ASN.1): Represents interactions, complexes, and pathways using an ASN.1 data specification that captures cellular location, experimental conditions, conserved sequences, molecular locations, chemical actions, kinetics, thermodynamics, and chemical states.
• Graphical analysis: Provides visualization of protein domain composition within interaction and complex records and offers interaction network clustering to examine specific network regions.
• Molecular complexes and pathways: Defines molecular complexes as collections of multiple interactions with topology annotations and defines pathways as collections of interactions with contextual details such as cell cycle stage.

Scientific Applications:

• High-throughput proteomics: Provides a standardized framework for identifying and characterizing proteins, protein domains, and their interactions from large-scale experimental data.
• Network and pathway analysis: Enables exploration and analysis of complex biological interaction networks and pathways.
• Systems biology and disease research: Supports investigations into cellular functions and disease mechanisms through integrated interaction and pathway data.

Methodology:

Data are represented using an ASN.1 specification capturing detailed molecular and experimental attributes, with computational features including protein domain composition visualization and interaction network clustering.