Bio-SeCo

Bio-SeCo integrates ranked search results from heterogeneous bioinformatics services to enable ranking-aware combination and exploratory analysis of distributed biomedical-molecular data for knowledge discovery.

Key Features:

• Integration of heterogeneous search services: Manages and integrates ranked results from external databases and services such as NCBI, WU BLAST, and Array Express.
• Search service modeling: Models a suite of bioinformatics search services within the Search Computing framework to represent service outputs and rankings.
• Ranking-aware combination: Combines results while preserving and exploiting source-provided ranking information to prioritize outcomes.
• Exploratory iterative search: Supports multiple search attempts with inspection, selection of relevant results, and iterative refinement of queries.
• Complex query construction: Enables construction and execution of complex queries across multiple distributed sources to integrate diverse data types.
• Support for data-driven discovery: Automates exploratory search processes to assist in synthesizing information across large, heterogeneous biomedical datasets.

Scientific Applications:

• Integrated exploration of biomedical-molecular data: Facilitates combined analysis of distributed datasets to derive coherent biological insights.
• Addressing multifaceted biomedical questions: Supports investigations spanning numerous molecular aspects by integrating diverse evidence sources.
• Evidence prioritization and ranking: Aids prioritization of candidate results and hypotheses through ranking-aware result combination.

Methodology:

Models bioinformatics search services within the Search Computing framework, manages and integrates ranked results from heterogeneous services (e.g., NCBI, WU BLAST, Array Express), applies ranking-aware combination of results, and supports iterative search, result inspection, selection, refinement, and construction of complex queries across distributed sources.