bioassayR

bioassayR analyzes large-scale bioassay datasets to evaluate compound–target interactions and generate high-throughput screening fingerprints for cross-target bioactivity analysis.

Key Features:

• Large-Scale Bioassay Analysis: Enables simultaneous analysis of thousands of bioassay experiments involving multiple compounds and biological targets.
• Cross-Target Bioactivity Evaluation: Supports comparative analysis across public and custom bioassays to assess compound selectivity and target druggability.
• High-Throughput Screening Fingerprints (HTSFPs): Generates HTSFP representations to summarize high-throughput screening data for efficient comparison across assays.
• Integrated Bioactivity Data Resources: Provides optional access to a preloaded database containing publicly available bioactivity screening data.

Scientific Applications:

• Drug Discovery Screening Analysis: Identifies compounds with favorable selectivity profiles across multiple biological targets.
• Target Druggability Assessment: Evaluates biological targets using aggregated bioactivity screening datasets.
• Bioactivity Data Mining: Supports comparative and meta-analysis of high-throughput screening experiments.

Methodology:

bioassayR processes large-scale bioassay datasets to compute cross-target bioactivity analyses and generate high-throughput screening fingerprints representing compound responses across multiple assays.