BioCircos.js

BioCircos.js renders circular visualizations of genomic data to represent genomic features, genetic variations, gene expression profiles, and biomolecular interactions for analysis of complex datasets.

Key Features:

• JavaScript library: Provides a client-side JavaScript implementation for generating circular biological visualizations.
• Circular layout rendering: Renders data in a circular layout to display relationships and positional information across genomes.
• Genomic feature visualization: Displays genomic features such as loci, regions, and annotations on circular plots.
• Genetic variation visualization: Represents genetic variations (e.g., variants) within the circular genomic context.
• Gene expression visualization: Visualizes gene expression profiles mapped to genomic coordinates on the circle.
• Biomolecular interaction visualization: Illustrates biomolecular interactions and connections between genomic elements within the circular view.
• Integration for web applications: Can be embedded into web-based applications to present diverse types of biological information.

Scientific Applications:

• Genomics: Visualizing large-scale genomic datasets and positional annotations on a unified circular layout.
• Variant analysis: Mapping and comparing genetic variations in the context of genome structure.
• Transcriptomics: Displaying gene expression profiles across genomic coordinates.
• Interactomics: Mapping biomolecular interactions and connections between genomic elements.

Methodology:

Implements circular layout rendering in JavaScript for web-based visualization of genomic features, genetic variations, gene expression profiles, and biomolecular interactions.