AffiXcan

AffiXcan imputes Genetically Regulated Expression (GReX) for a set of genes in a sample of individuals using a method based on Total Binding Affinity (TBA).

Key Features:

• GReX Imputation: Imputes GReX for a set of genes in a sample of individuals.
• Total Binding Affinity-based Method: Uses a method based on TBA to perform imputation.
• Statistical Model Training: Statistical models to impute GReX can be trained with a training dataset where the real total expression values are known.

Scientific Applications:

• Genetically Regulated Expression Analysis: Enables imputation of GReX when real total expression values are known in training data.

Methodology:

AffiXcan uses a method based on Total Binding Affinity (TBA) to impute GReX, with statistical models trained on datasets containing known real total expression values.