atacInferCnv

atacInferCnv prepares input scATAC-seq data and adapts it for copy number variation profiling using the InferCNV package.

Key Features:

• External Normal Reference Usage: Supports incorporation of external normal reference data for CNV calling.
• Meta-cell Analysis: Enables meta-cell generation as a parameter for controlling analysis.
• Bin Size Control: Allows users to specify bin size as a configurable analysis parameter.
• Custom Plot Visualizations: Provides custom visualization options for CNV profiling results.

Scientific Applications:

• Single-Cell ATAC-seq CNV Profiling: Enables detection of copy number variation from single-cell ATAC-seq data through adaptation of the InferCNV framework.

Methodology:

The package prepares input scATAC-seq data and adapts it for use with the InferCNV package for copy number variation profiling.