Cepo

Cepo explores cell identities from single-cell RNA-sequencing data by computing cell-type specific gene statistics using differential stability as a metric to define cell identity genes.

Key Features:

• Differential Stability Metric: Cepo uses differential stability as a new metric to define cell identity genes, quantifying the consistency of gene expression within cell types.
• Cell-Type Specific Gene Statistics: Cepo computes statistics pertaining to differential stable gene expression for identifying genes that define cell identity.

Scientific Applications:

• Cell Identity Definition: Cepo enables the exploration of cell identities to understand cellular heterogeneity in response to environmental signals and perturbations.
• Single-Cell RNA-Sequencing Analysis: Cepo is applied to single-cell RNA-sequencing datasets to identify genes that characterize distinct cell types.

Methodology:

Cepo computes cell-type specific gene statistics pertaining to differential stable gene expression.