CHRONOS

CHRONOS unravels the inherent dynamic properties of pathways by extracting and evaluating microRNA-mediated subpathway topologies through temporal transition and fold change activity of linked genes and microRNAs.

Key Features:

• Subpathway topology extraction: MicroRNA-mediated subpathway topologies are extracted from pathway data.
• Temporal transition analysis: Temporal transition of linked genes and microRNAs is exploited for dynamic evaluation.
• Fold change activity integration: Fold change activity of linked genes and microRNAs is incorporated into the evaluation framework.

Scientific Applications:

• Time-varying sub-pathway enrichment analysis: Enables microRNA-mediated sub-pathway enrichment analysis with temporal dynamics.
• Dynamic pathway analysis: Supports efficient unraveling of inherent dynamic properties in biological pathways.

Methodology:

The method exploits temporal transition and fold change activity of linked genes and microRNAs to extract and evaluate microRNA-mediated subpathway topologies.