CuratedAtlasQueryR

CuratedAtlasQueryR provides access to a copy of the Human Cell Atlas with harmonised metadata, enabling uniform querying across numerous datasets within the Atlas using common fields such as cell type, tissue type, and patient ethnicity.

Key Features:

• Harmonised Metadata Querying: Enables uniform querying across numerous datasets within the Human Cell Atlas using common fields such as cell type, tissue type, and patient ethnicity.
• Metadata-Based Cell Selection: Supports querying the metadata table for cells of interest prior to data retrieval.
• SingleCellExperiment Output: Downloads corresponding cells into a SingleCellExperiment object.

Scientific Applications:

• Human Cell Atlas Data Access: Facilitates standardised access to harmonised single-cell data from the Human Cell Atlas for downstream analysis.
• Cross-Dataset Cell Type Comparison: Enables identification and comparison of specific cell populations across diverse datasets using unified metadata fields.

Methodology:

Usage involves first querying the metadata table for cells of interest, and then downloading the corresponding cells into a SingleCellExperiment object.