deltaCaptureC

deltaCaptureC discovers meso-scale chromatin remodelling from 3C data by testing for statistically significant changes in interaction counts between restriction enzyme digestion fragments and a preferred 'viewpoint' region across two cell types or two treatments.

Key Features:

• 3C data binning: Bins interaction count data between restriction enzyme digestion fragments and a preferred 'viewpoint' region.
• Permutation testing: Applies permutation testing to assess statistical significance of changes in interaction counts.
• Differential interaction analysis: Compares interaction counts between data from two cell types or two treatments.

Scientific Applications:

• Meso-scale chromatin remodelling detection: Identifies meso-scale chromatin structural changes from 3C data.
• Comparative chromatin conformation analysis: Detects condition-specific differences in local chromatin interactions between cell types or treatments.

Methodology:

The method involves binning 3C interaction count data and applying permutation testing to evaluate statistically significant changes in interaction counts between two conditions.