DEWSeq

DEWSeq implements a sliding window approach for the analysis of differentially enriched binding regions in eCLIP or iCLIP next generation sequencing data.

Key Features:

• Sliding Window Analysis: DEWSeq employs a sliding window approach to identify differentially enriched binding regions.
• Negative Binomial Distribution: The method is based on the negative binomial distribution for statistical modeling.
• eCLIP/iCLIP Compatibility: The tool specifically supports enhanced CLIP (eCLIP) and individual-nucleotide resolution CLIP (iCLIP) sequencing data.

Scientific Applications:

• RNA-Binding Protein Analysis: DEWSeq enables identification of differentially enriched binding regions from crosslinking and immunoprecipitation sequencing experiments.

Methodology:

DEWSeq uses a sliding window approach based on the negative binomial distribution.