drugfindR

drugfindR provides programmatic access to LINCS Signatures from the iLINCS database and enables identification of concordant and discordant signatures against user-supplied transcriptomic signatures for candidate drug repurposing.

Key Features:

• LINCS Signature Access: Retrieves Consensus Gene Knockdown Signatures, Gene Overexpression Signatures, and Chemical Perturbagen Signatures from the iLINCS database.
• Signature Comparison: Identifies concordant and discordant signatures between user-entered transcriptomic signatures and the LINCS database.

Scientific Applications:

• Drug Repurposing: Investigates candidate repurposable drugs by matching transcriptomic signatures to chemical perturbagen and genetic manipulation signatures in LINCS.
• Transcriptomic Signature Analysis: Enables comparison of custom gene expression signatures against large-scale perturbation databases to infer functional relationships.

Methodology:

The package accesses the iLINCS database to retrieve LINCS Signatures and performs signature concordance and discordance analysis against user-provided transcriptomic signatures.