fenr

fenr performs fast functional enrichment on feature lists such as genes or proteins using the hypergeometric distribution.

Key Features:

• Fast enrichment testing: Performs functional enrichment using the hypergeometric distribution optimized for speed.
• Multiple database support: Supports retrieval of functional data from GO, KEGG, Reactome, Bioplanet, and WikiPathways.
• Pre-cached data preparation: Downloads and prepares functional data first to enable rapid successive tests on various feature selections without repetitive preparatory steps.

Scientific Applications:

• Gene and protein list analysis: Enables functional enrichment analysis on feature lists such as genes or proteins.
• Interactive analysis workflows: Supports rapid iterative enrichment testing for interactive platforms requiring successive feature selection tests.

Methodology:

Functional enrichment is performed using the hypergeometric distribution, with functional data retrieved from GO, KEGG, Reactome, Bioplanet, and WikiPathways and pre-downloaded and prepared to allow rapid successive tests.