genomicInstability

genomicInstability performs genomic instability analysis (GIA) from scRNA-Seq data to estimate the association between gene expression and genomic location of coding genes and derive a Genomic Instability Score (GIS) for each cell.

Key Features:

• Genomic Instability Analysis (GIA): Estimates the association between gene expression and genomic location of coding genes from scRNA-Seq data.
• aREA Algorithm Integration: Quantifies the enrichment of sets of contiguous genes (loci-blocks) on gene expression profiles.
• Genomic Instability Score (GIS) Estimation: Computes a GIS for each analyzed cell based on loci-block enrichment patterns.

Scientific Applications:

• Single-Cell Genomic Instability Profiling: Enables cell-level assessment of genomic instability from scRNA-Seq transcriptomic data.

Methodology:

The aREA algorithm is used to quantify the enrichment of sets of contiguous genes (loci-blocks) on gene expression profiles.