GeoDiff

GeoDiff implements statistical models using count generating distributions for background modelling, feature and sample quality control, normalization, and differential expression analysis on GeoMx RNA data.

Key Features:

• Background Modelling: Uses count generating distributions to model background noise in GeoMx RNA data.
• Feature QC: Performs quality control at the feature level for GeoMx RNA data.
• Sample QC: Performs quality control at the sample level for GeoMx RNA data.
• Normalization: Normalizes GeoMx RNA count data using count model-based approaches.
• Differential Expression Analysis: Conducts differential expression analysis on GeoMx RNA data using count generating distributions.

Scientific Applications:

• GeoMx RNA Data Analysis: Supports end-to-end analysis workflows for NanoString GeoMx Digital Spatial Profiler RNA data including quality control, normalization, and differential expression.

Methodology:

Statistical models using count generating distributions.