GOfan

GOfan visualizes Gene Ontology (GO) enrichment results using a sunburst layout that preserves hierarchical relationships among GO terms and enables color-based encoding of information such as p-values or gene counts.

Key Features:

• Sunburst layout visualization: Converts complex GO directed acyclic graphs (DAGs) into circular representations that display hierarchical structure of enriched terms.
• Color-based encoding: Supports mapping of numerical information such as p-values or gene counts to color scales for visual interpretation.
• Hierarchical relationship preservation: Maintains parent-child relationships among GO terms in the displayed layout, inspired by SynGO.
• Interactive and customizable visualizations: Enables exploration of key GO categories through adjustable display parameters.

Scientific Applications:

• GO enrichment analysis interpretation: Facilitates biological interpretation and presentation of enrichment analysis results by displaying the hierarchical structure and significance of enriched GO terms.

Methodology:

GOfan converts Gene Ontology directed acyclic graphs into sunburst plot representations using a layout approach inspired by SynGO.