goSorensen

goSorensen implements inferential methods to compare gene lists in terms of their biological meaning as expressed in the Gene Ontology (GO).

Key Features:

• Gene list comparison: Compares gene lists using cross-tabulation frequency tables of enriched GO items.
• Dissimilarity measurement: Evaluates dissimilarity between gene lists using the Sorensen-Dice index.
• Similarity assessment: Determines that two gene lists are similar if they share a great proportion of common enriched GO items.

Scientific Applications:

• Functional comparison of gene lists: Assesses biological similarity between gene lists based on their GO enrichment profiles.
• GO-based inference: Performs statistical inference on gene list relationships using GO annotations.

Methodology:

The package characterizes compared gene lists by cross-tabulation frequency tables of enriched GO items and evaluates dissimilarity using the Sorensen-Dice index.