HiCaptuRe

HiCaptuRe provides tools to import, annotate, manipulate, and export Capture Hi-C data, accounting for the specific structure of bait–otherEnd interactions to facilitate integration with other omics datasets and enable comparison across samples and conditions.

Key Features:

• Data Import and Export: HiCaptuRe supports importing and exporting Capture Hi-C data in formats appropriate for bait–otherEnd interaction structures.
• Annotation: HiCaptuRe provides annotation capabilities specific to Capture Hi-C datasets involving baits and otherEnds.
• Data Manipulation: HiCaptuRe enables manipulation of Capture Hi-C data while preserving the specific structure of bait–otherEnd interactions.
• Multi-omics Integration: HiCaptuRe facilitates integration of Capture Hi-C data with other omics datasets.
• Comparative Analysis: HiCaptuRe enables comparison of Capture Hi-C data across samples and conditions.

Scientific Applications:

• Capture Hi-C Analysis: HiCaptuRe supports analysis of genomic interactions involving selected loci (baits) at restriction fragment resolution with reduced sequencing costs compared to conventional Hi-C.
• Multi-omics Data Integration: HiCaptuRe enables researchers to integrate Capture Hi-C interaction data with complementary omics datasets for comprehensive genomic studies.
• Comparative Genomics: HiCaptuRe allows comparison of chromatin interaction patterns across different biological samples and experimental conditions.

Methodology:

The package accounts for the specific structure of bait–otherEnd interactions inherent to Capture Hi-C data.