HIREewas

HIREewas implements the HIgh REsolution (HIRE) statistical model for detecting cell-type-specific risk-CpG sites in epigenome-wide association studies.

Key Features:

• Aggregated association detection: Improves statistical power for detecting CpG-phenotype associations at the aggregated sample level compared to existing methods.
• Cell-type-specific resolution: Enables identification of risk-CpG sites within individual cell types rather than only at the bulk tissue level.
• Deconvolution of mixed methylation signals: Accounts for measured signals being mixtures of methylation profiles from different cell types.

Scientific Applications:

• Epigenome-wide association studies: Determines which specific cell types harbor phenotype-affected risk-CpG sites in complex tissues with heterogeneous cell composition.

Methodology:

The HIRE statistical model.