immunotation

immunotation provides tools for consistent annotation of HLA genes in immunoinformatics workflows such as MHC-presented peptide prediction in different human donors.

Key Features:

• HLA naming scheme conversion: Converter functions provide mappings between different HLA naming schemes based on the MHC restriction ontology (MRO).
• Allele frequency access: Automated access to HLA allele frequencies in worldwide human reference populations stored in the Allele Frequency Net Database.

Scientific Applications:

• MHC peptide prediction: Consistent HLA annotation supports prediction of MHC-presented peptides in different human donors.
• Population immunogenetics: Access to population-specific HLA allele frequencies enables comparative studies across human populations worldwide.

Methodology:

Converter functions for HLA naming scheme mappings are based on the MHC restriction ontology (MRO).