LACHESIS

LACHESIS analyzes tumor evolution from whole genome sequencing data by estimating mutation densities at genomic segments and using these to time the origin of the tumor.

Key Features:

• Mutation density estimation: Provides estimates of mutation densities at genomic segments from whole genome sequencing data.
• Tumor timing: Uses mutation density estimates to time the origin of the tumor.

Scientific Applications:

• Early tumor evolution analysis: Analyzes early tumor evolution from whole genome sequencing data.
• Tumor origin dating: Times the origin of tumors based on mutation density patterns across genomic segments.

Methodology:

The package estimates mutation densities at genomic segments and uses these estimates to time the origin of the tumor.