magpie

magpie performs power analysis for MeRIP-seq studies to evaluate statistical performance under varying experimental parameters.

Key Features:

• FDR calculation: Calculates false discovery rate under various study design parameters.
• FDC calculation: Calculates false discovery cost under various study design parameters.
• Power calculation: Calculates statistical power under various study design parameters.
• Precision calculation: Calculates precision under various study design parameters.
• Study design parameter evaluation: Evaluates performance across sample size, sequencing depth, and testing method parameters.
• Excel output: Outputs results into .xlsx files.
• Figure generation: Produces corresponding figures of choice.

Scientific Applications:

• MeRIP-seq experimental design: Informs optimal sample size and sequencing depth decisions for methylated RNA immunoprecipitation sequencing studies.
• Statistical method comparison: Compares testing methods for MeRIP-seq data analysis through power and error rate evaluation.

Methodology:

The methodology is not explicitly detailed in the provided sources.