MesKit

MesKit provides analysis and visualization modules for mutational data generated by multi-region sequencing (MRS) to dissect cancer evolution from multi-region derived tumor biopsies via somatic alterations.

Key Features:

• Mutational profile depiction: Generates visual representations of mutational profiles from MRS data.
• Heterogeneity measurement: Quantifies heterogeneity within or between tumors from the same patient.
• Evolutionary dynamics tracking: Tracks evolutionary dynamics across tumor regions.
• Mutational pattern characterization: Characterizes mutational patterns at different biological levels.

Scientific Applications:

• Tumor heterogeneity interpretation: Facilitates interpretation of intra-tumor and inter-tumor heterogeneity in MRS studies.
• Evolutionary relationship analysis: Supports understanding of evolutionary relationships between spatially distinct tumor regions.
• Cancer evolution dissection: Enables investigation of cancer evolutionary processes from multi-region derived tumor biopsies.

Methodology:

MesKit analyzes somatic alteration data from multi-region sequencing to measure heterogeneity, track evolutionary dynamics, and characterize mutational patterns.