metapod

metapod implements methods for combining p-values in differential analyses of genome-scale datasets.

Key Features:

• Within-analysis p-value combination: Combines p-values across different tests in the same analysis, such as genomic windows in ChIP-seq or exons in RNA-seq.
• Across-analysis p-value combination: Combines p-values for corresponding tests across separate analyses, such as replicated comparisons or effects of different treatment conditions.
• Input handling: Supports log-transformed input p-values, missing values, and weighting where appropriate.

Scientific Applications:

• ChIP-seq analysis: Combines p-values across genomic windows in differential binding analyses.
• RNA-seq analysis: Combines p-values across exons in differential expression or splicing analyses.
• Replicated comparisons: Integrates statistical evidence across replicated experiments or different treatment conditions.

Methodology:

The package implements a variety of established statistical methods for p-value combination, with support for log-transformed inputs, missing value handling, and weighted combination where appropriate.