MIRA

MIRA aggregates genome-scale DNA methylation data into a DNA methylation profile for a given region set with shared biological annotation and infers and scores the collective regulatory activity for the region set.

Key Features:

• Region set aggregation: MIRA aggregates genome-scale DNA methylation data into a DNA methylation profile for a given region set with shared biological annotation.
• Regulatory activity scoring: MIRA infers and scores the collective regulatory activity for the region set using the DNA methylation profile.
• Leveraging public region sets: MIRA allows public sources of region sets to be leveraged for novel insight into the regulatory state of DNA methylation datasets.

Scientific Applications:

• Regulatory analysis in challenging contexts: MIRA facilitates regulatory analysis in situations where classical regulatory assays would be difficult.
• Regulatory state inference: MIRA enables novel insight into the regulatory state of DNA methylation datasets.

Methodology:

MIRA aggregates genome-scale DNA methylation data into a DNA methylation profile for a given region set with shared biological annotation, then uses this profile to infer and score the collective regulatory activity for the region set.