NPARC

NPARC performs non-parametric analysis of response curves for thermal proteome profiling experiments to reveal drug-binding proteins.

Key Features:

• Non-parametric analysis: Analyzes response curves without assuming a specific parametric form for the data distribution.
• Thermal proteome profile analysis: Processes thermal proteome profiling data to detect protein stability changes.

Scientific Applications:

• Drug-binding protein discovery: Identifies novel drug-binding proteins through analysis of thermal stability shifts in proteome-wide experiments.
• Thermal proteome profiling: Enables detection of protein-ligand interactions by measuring changes in protein melting curves upon compound treatment.

Methodology:

Non-parametric analysis of response curves as described by Childs, Bach, Franken et al. (2019).