PanomiR

PanomiR detects miRNAs that target groups of pathways from gene expression data.

Key Features:

• Pathway Activity Profiling: Generates pathway activity profiles from gene expression data.
• Differential Pathway Analysis: Determines differentially activated pathways between user-specified conditions.
• Pathway Clustering: Determines clusters of pathways via the PCxN package.
• miRNA Target Prediction: Generates miRNAs targeting clusters of pathways.
• Modular Analysis: Functions can be used separately or sequentially to analyze RNA-Seq data.

Scientific Applications:

• RNA-Seq Data Analysis: Analyzes RNA-Seq data to identify miRNA-mediated regulation of pathway groups.
• Pathway Interaction Studies: Investigates miRNAs that regulate interacting groups of pathways rather than individual pathways.

Methodology:

The package uses the PCxN package for determining clusters of pathways.