parati

parati infers maternal and paternal transmitted and non-transmitted alleles from phased trio genotype data to support SNP-level analyses of genetic nurture and transgenerational effects.

Key Features:

• Phased trio genotype analysis: Infers maternal and paternal transmitted and non-transmitted alleles from phased trio genotype data.
• SNP-level effect analysis: Supports SNP-level analyses of genetic nurture and transgenerational effects.
• Bioconductor VCF interoperability: Interoperates with Bioconductor VCF infrastructure through support for VariantAnnotation::VCF objects.
• Downstream analysis compatibility: Returns R objects for downstream analysis.

Scientific Applications:

• Genetic nurture analysis: Enables SNP-level investigation of genetic nurture effects in family-based genetic studies.
• Transgenerational effect analysis: Supports SNP-level analyses of transgenerational effects using trio genotype data.

Methodology:

Inference of maternal and paternal transmitted and non-transmitted alleles from phased trio genotype data, with support for VariantAnnotation::VCF objects.