pfamAnalyzeR

pfamAnalyzeR enables the identification and classification of domain isotypes from Pfam data in R.

Key Features:

• Pfam Data Import: Reads Pfam predictions from both webserver and stand-alone runs into R.
• Domain Isotype Identification: Identifies multiple distinct variants of protein domains termed domain isotypes.
• Domain Isotype Classification: Classifies domain isotypes from Pfam data.

Scientific Applications:

• Domain Isotype Analysis: Analyzes domain isotypes that are used in a cell, tissue, and disease-specific manner.
• Functional Impact Assessment: Compares domain isotypes to determine how they modulate or abolish the functionality of a protein domain.

Methodology:

The package reads Pfam predictions into R for identification and classification of domain isotypes.