RBedMethyl

RBedMethyl provides Bioconductor-native infrastructure for handling large nanoporetech modkit bedMethyl pileup files from ONT data using HDF5Array and DelayedArray.

Key Features:

• Disk-backed representation: Enables efficient storage and access of large nanoporetech modkit bedMethyl pileup files without loading entire datasets into memory.
• HDF5Array integration: Utilizes HDF5Array for backend array storage and manipulation of methylation data.
• DelayedArray integration: Leverages DelayedArray for deferred and block-processed computations on methylation datasets.

Scientific Applications:

• Oxford Nanopore Technologies DNA methylation analysis: Supports analysis of modkit bedMethyl pileup files generated from ONT sequencing data.

Methodology:

RBedMethyl uses HDF5Array and DelayedArray to provide disk-backed representation of nanoporetech modkit bedMethyl pileup files from ONT data.