REBET

REBET implements the subREgion-based BurdEn Test, a powerful burden test that simultaneously identifies susceptibility loci and sub-regions associated with rare variants and diseases.

Key Features:

• Burden Test Framework: Implements a powerful burden test for rare variant association analysis.
• Dual Identification: Simultaneously identifies susceptibility loci and sub-regions in a single analytical framework.

Scientific Applications:

• Rare Variant Association Studies: Investigates the association between rare variants and diseases.
• Susceptibility Locus Mapping: Identifies genomic regions harboring disease-associated rare variants.
• Sub-region Localization: Pinpoints specific sub-regions within loci that drive disease associations.

Methodology:

The subREgion-based BurdEn Test.