RegEnrich

RegEnrich implements a pipeline to identify key gene regulators in biological processes such as cell differentiation and cell development after stimulation.

Key Features:

• Differential Expression Analysis: Performs the first step of the pipeline to quantify gene expression changes.
• Regulator-Target Network Inference: Reconstructs regulatory relationships between regulators and their target genes.
• Enrichment Analysis: Assesses the statistical significance of regulator-target associations.
• Regulator Scoring and Ranking: Scores and ranks candidate regulators to prioritize key regulatory factors.

Scientific Applications:

• Cell Differentiation Studies: Identifies master regulators driving cell type transitions.
• Cell Development After Stimulation: Pinpoints critical regulatory genes controlling cellular responses to external stimuli.

Methodology:

The pipeline consists of four major steps: (1) differential expression analysis; (2) regulator-target network inference; (3) enrichment analysis; and (4) regulators scoring and ranking.